44 Seed AI & Machine Learning Investors in San Francisco — 43 Currently Deploying

Bee Partners backs radical technical founders at inception (pre-product, pre-revenue) with conviction-first capital. They invest in AI supercycle futures, enterprise AI agents, har…

YC turns builders into formidable founders by providing structured mentorship, funding, and network access during a 12-week batch program. The program transforms early-stage teams …

Invest first in founders making mutants a reality by reimagining the universe. Generalist investors backing companies that make 1 billion lives better through bold bets in deep tec…

South Park Commons helps talented technologists and founders turn 'illegible into the inevitable' by providing a home for figuring out what's next, transitioning from -1 to 0 (pre-…

Operator Collective is an early-stage B2B venture firm that connects founders to exceptional enterprise operators, believing companies succeed because of the people who build them.

Offer founders pursuing their life's work an alternative to the hype cycle by providing long-term thinking and supporting category-defining companies across all sectors that will l…

Write the first check to builders who are still dreaming, tinkering, and exploring what they want to create. Work with founders pre-product, pre-traction, and often pre-idea.

Lead and co-lead Series A and Seed rounds in companies with early signs of product-market fit, focusing on consumer technology and consumerization of enterprise technology.

Accelerating AI-native founders at the earliest stages. Lead early rounds in companies and founders building the future, providing that first check before others think you're onto …

Partner with bold technical founders from inception, before product or first check, backing AI-native infrastructure, security, apps, and models to build the autonomous enterprise.

Pre-seed venture fund leading investments in Intelligent Industry Solutions, focused on AI-led innovation that delivers radical productivity, industrial efficiency through percepti…

We back founders building things the world hasn't seen yet, at the moment before the world believes. We are a specialized and scaled seed fund designed to actually deliver with dee…

Amplify invests in technical founders building the next generation of applications, models, tools, and infrastructure. For almost 15 years they have been the first investor and par…

Bold, early, impactful ventures with brutal honesty. Believe in world-class teams making contrarian bets on impossibly big ideas, from AI to cleantech to deep tech.

Support audacious entrepreneurs building consumer technology that transforms how billions experience the world through connectivity, convenience, entertainment and empowerment, inv…

NFX identifies and backs founders building companies with network effects. The fund emphasizes software development, founder support through content/tools, and emerging technologie…

Backing outlier founders at the earliest stages.

Atomic functions as a co-founder replacement, providing serial entrepreneurs, specialist teams, and resources to de-risk company building and accelerate time to market while founde…

Early stage B2B-focused venture firm specializing in building enterprise leaders through disruptive B2B AI software investments in enterprise infrastructure, cybersecurity, and rel…

Experienced founders (particularly serial/exit founders) win 22x more often. Zero-equity retreats attract elite repeat founders who avoid traditional accelerators, enabling first-m…

Neo invests in people and the next generation of founders through pre-seed/seed funding, a startup residency program, and a diverse mentorship community. The fund believes in suppo…

Specialists in pre-seed and seed investing, founded by operators who have built and scaled companies. Provide hands-on support through recruiting, GTM coaching, fundraising assista…

The product-market fit partner for technical enterprise founders, turning product-market fit from improbable to inevitable through proprietary playbook and methodology.

We're aligned with founders for the long haul, investing at the earliest stages with sector-agnostic conviction in exceptional entrepreneurs. We believe in founder alignment, early…

Back the world's best AI native founders at pre-seed and seed stages with product and go-to-market expertise from OpenAI, Meta, Twitter, and a16z to help them reshape the world.

Lead seed rounds and partner with founders from 0 to 1

Air Street Capital invests in AI-first companies as early as possible, iterating through product, market and technology strategy from day 1 to create enduring companies with lastin…

Partner at inception with technically brilliant founders who see past impossible to inevitable. Invest in technical breakthroughs becoming world-changing companies, particularly in…

Back visionary and relentless founders building the future using technology and science. Belief in AGI for good, decentralized systems, personalized well-being, quiet electric tran…

Canaan invests in visionaries with transformative ideas where science and technology become society. The firm focuses on early-stage companies that break the mold to bring spectacu…

First-check investor (pre-seed, seed, series A) deeply focused on AI-first companies. Partners selectively, cares deeply, and strives for excellence in reshaping industries through…

First believers in AI Native founders, providing zero to one capital and hands-on support for builders of AI Native applications, infrastructure, and developer tools.

Invest in technical founders building software that will improve millions of consumers' lives. Back bold founders with a vision worth fighting for.

First Round partners with unreasonable founders at the earliest stages to help them imagine and build transformative companies. The fund focuses on being the world's best partner f…

First institutional investor for early-stage AI founders, with 70% of investments beginning at inception. People-first approach to building breakthrough companies.

Paradigm builds and invests across crypto, AI, robotics, and other new frontiers, with a focus on advancing the frontier for everyone through software development and open source c…

Providing resources and counsel to forward-thinking companies revolutionizing how we live, work, and play, with favorable terms and less dilution than traditional VC models.

Designer Fund invests in early stage tech companies that use design to improve health, sustainability, or prosperity for all people.

Help mission-driven pioneers win by harnessing storytelling, art and culture. Back early-stage companies with customer obsession in their DNA and accelerate mass adoption of techno…

Air Street Capital invests in AI-first companies as early as possible, iterating through product, market and technology strategy from day 1 to create enduring companies with lastin…

Piva Capital invests in people, companies, and breakthrough technologies at the inflection of scientific breakthrough and mass market impact to usher in a new industrial era across…

Baukunst is a collective of creative technologists advancing the art of building through pre-seed investments in companies at the frontiers of technology and design.

Alchemist guides technical founders on the journey from possibility to traction by transforming technical builders into CEOs ready to scale through intensive coaching, investor acc…

Partner with entrepreneurs from early days through every stage of growth, focusing on transformative technology across AI/ML, biotech, cloud, consumer, and crypto sectors.

How many seed ai & machine learning investors are actively deploying right now?

DryPowder tracks 44 seed ai & machine learning funds. Of these, 43 are currently deploying capital based on recent fund closes, portfolio activity, and partner signals. Use DryPowder's fund matching to see which ones fit your specific startup.

What check size do seed ai & machine learning VCs write?

Among 44 seed ai & machine learning funds on DryPowder, check sizes run from $25K–$50M. Ranges vary by fund size, vintage, and whether the fund leads rounds. Each fund profile shows check size detail and lead preference.

How do I get a meeting with a seed ai & machine learning VC?

A warm intro is still the fastest path. Most seed ai & machine learning VCs on DryPowder do accept cold outreach or direct applications, but response rates vary widely by fund. Before reaching out, use DryPowder's AI matching to get a fit score and specific talking points. Founders who lead with thesis-aligned framing get significantly better response rates than those sending the same deck to every fund on a list.

How long does a seed round typically take to close?

Seed rounds typically take 3-6 months from first meeting to close. Most of that time is spent on qualification: investors want to see early traction, run multiple meetings, and often complete reference checks. With a committed lead who sets terms, the rest of the round usually fills within 2-4 weeks. Without a lead, the process drags. DryPowder's deployment signals help identify which seed funds are actively writing checks right now versus sitting between vehicles.

How many seed ai & machine learning investors should I be talking to at once?

Most fundraisers recommend a parallel process: identify 20-40 target investors but approach your highest-fit funds first. Of the 43 seed ai & machine learning funds currently deploying, not all will match your specific stage and sector. Use fund matching to find your top 10-15, approach those first, collect feedback, then go wider. Going to every fund simultaneously without qualifying first burns bridges and dilutes the urgency that helps close a round.

How is DryPowder different from building a VC list on LinkedIn or Crunchbase?

The fund list you build on LinkedIn or Crunchbase is roughly the same list every other founder is building. DryPowder adds three things a manual search cannot: deployment signals (which funds have recently closed new vehicles and are actively writing checks), AI thesis matching (which of the 44 seed ai & machine learning funds actually fits your specific startup, ranked by fit), and verified partner contact details. The goal is 15 targeted, thesis-aligned pitches instead of 150 generic ones.